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ANAAAAAAAAAAFAAAACAAAAABAAAAAQAAAAAAAAABAAAArAAAAAgAAAAEAAAAAAAAAQAAAAABAAAA AAAAAQEAAAABAAAAAAAAAQIAAAABAAAAAAAAAQMAAAABAAAAAAAAAQQAAAABAAAAAAAAAQUAAAAs bmFtZAAAACQAAAABAAAABAAAAAEAAAAAAAAAAAAAAApNUyBQR290aGljAAAAAAEGAAAABAAMAAAA AAEHAAAABgAAAAAAAAAAAAQAAAAOAAkAEQAAABoAAQAAAAAAAAvwBAAAABI0Vng= ------=_NextPart_01C8AF8E.34C0B340 Content-Location: file:///C:/E18B19E5/Muscle_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Using biophysical techniques to elucidate muscle structure and funct= ion
Use of Biophysical and Biochemical techniques to <= /span>elucidate myosin structure and function
I have discovered that all human evil comes from this, man's= being unable to sit still in a room.
Blaise Pascal
French mathematician, physicist (1623 - 1662)
=
------=_NextPart_01C8AF8E.34C0B340 Content-Location: file:///C:/E18B19E5/Muscle_files/slide0005.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Using biophysical techniques to elucidate muscle structure and funct= ion
Motor proteins
•Ubiquitous in eukaryotes
•<= /span>Responsible for a wide range of functions requiring directed moveme= nt of molecules, subcellular components, cells, tissues and = whole organisms
•<= /span>Motor proteins utilize the energy of hydrolysis of NTP
------=_NextPart_01C8AF8E.34C0B340 Content-Location: file:///C:/E18B19E5/Muscle_files/slide0006.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Using biophysical techniques to elucidate muscle structure and funct= ion
3Dsarcomereanimcropped
Skeletal Muscle
Myosins are actin-associated motor proteins=
= Muscle is comprised of interdigitating = filaments of actin and myosin = polymers
= During muscle contraction, myosin = heads move over and bind to an = adjacent actin filament. (Swinging <= span style=3D'position:absolute;top:44.5%;left:54.3%;width:42.32%;height:4.0%'>= Cross-Bridge Hypothesis)
<= span style=3D'font-size:75%'>Hydrolysis of ATP in the myosin head = results in a conformational change in = the myosin which causes the neck to = = swing, pulling on the actin filament. =
= The net result of many actin-myosin = <= span style=3D'font-size:75%'>interactions is that the filaments slide, <= /span><= span style=3D'font-size:75%'>relative to one another, causing the = muscle fiber to shorten (Sliding = Filament Hypothesis)
There = are three major types of muscle protein, cardiac (heart) muscle, skeletal and smooth muscle. Each type of muscle is comprised of interdigitating filaments of actin and myosin. Upon the initiation of a muscle contraction, myosin hea= ds move over and bind to an adjacent actin filament. Hydrolysis of ATP in the myosin head results in a conformational change in the myosin which causes= the neck to swing, pulling on the actin filament. The net result of many actin-myosin interactions is that the filaments slide, relative to one another, causing the muscle fiber to shorten.

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Non-mus= cle Myosins
There = are many other classes of myosin molecules in non-muscle cells, which interact with actin filaments in the cytoskeleton.  These myosins are responsible for a wide range of different proces= ses in the cell. Myosin V and VI are both double-headed myosins which ‘walk’ along actin filaments in a processive manner.
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