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Cynthia Corley Mastick

 
Photo of Cynthia Corley Mastick

Associate Professor
Department of Biochemistry and Molecular Biology
University of Nevada/Mail Stop 330
1664 North Virginia Street
Reno,  Nevada   89557

 

Office: (775) 784-1155
Lab: 327-2229
Fax: 784-1419
Email: cmastick@unr.edu
Building: Howard Medical Science,  Office 148

 

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EDUCATION

B.Sc. Biochemistry, 1985 Carnegie Mellon University, Pittsburgh, PA
Ph.D. Cellular and Molecular Biology, 1990 Carnegie Mellon University, Pittsburgh, PA

 
 
ACCOMPLISHMENTS

22 peer reviewed publications that have been cited more than 1400 times.

Invited Reviews
1)Mastick, C.C., M. Brady, JA Printen, V. Ribon, and A.R. Saltiel (1998) Spatial Determinants of Specificity in Insulin Action. Mol. Cell. Biochem. 182 (1-2): 65-71
2)Mastick, C.C., A.R. Sanguinetti, Cao, H. and Thakker, S. (2006) Phosphorylation of Caveolin and Signaling from Caveolae. In "Lipid Rafts & Caveolae" (C. J. Fielding, Ed.) Wiley-VCH, Weinheim.


Invited presentations:
1) American Society for Cell Biology, Annual Meeting, Special Interest Group, Endocytosis Mutants, 1987.
2) The New England Insulin Action Symposium, 1992.
3) American Society for Cell Biology, Annual Meeting, Minisyposium on Endocytosis and Exocytosis, 1992. 4) American Diabetes Association, 55th Annual Meeting, Scientific Sessions, Signal Transduction II, 1995. 5) FASEB Summer Research Conference, Recent Advances in Glucose Transporter Biology, 1995.
6) ASBMB Fall Symposium, Determinants of Specificity of Growth Factor Signaling, 1995.
7) International Congress Cell Biol. /ASCB, Symposium, Caveolae and GPI-Anchored Proteins, 1996.
 8) FASEB Summer Research Conference, Recent Advances in Glucose Transporter Biology, 1997.
9) Experimental Biology ’99, Symposia: Role of Plasmalemmal Caveolae in Signal Transduction, 1999.
10) FASEB Summer Research Conference, Recent Advances in Glucose Transporter Biology, 2003.
11) Keystone Symposia on Lipid Ordered Domains, 2004.
12) FASEB Summer Research Conference, Recent Advances in Glucose Transporter Biology, 2005.
13) Keystone Symposia on Lipid Rafts and Cell Function, March 2006.
 
AWARDS, HONORS, & PROFESSIONAL RECOGNITION

Competitive Individual National Fellowships and Grants:

Active

1) NIH R01 “Caveolae in Insulin Signaling”. 1999-2008.

Completed

1) American Predoctoral Fellowship, American Association of University Women, 1988.
2) Postdoctoral fellowship, Juvenile Diabetes Foundation International, 1991-1993.
3) American Diabetes Association Career Development Award, “Role of caveolin phosphorylation in insulin signalling”. 1999.
 4) American Diabetes Association Innovation Award, "Synapsin II dependent regulation of GluT4 exocytosis". 2003-05.
 
REPRESENTATIVE PUBLICATIONS

 

Older Publications

Cain, CC, WS Trimble, and GE Lienhard (1992) Members of the VAMP Family of Synaptic Vesicle Proteins are Components of Glucose Transporter-containing Vesicles from Rat Adipocytes. Accelerated Publication, J. Biol. Chem., 267, 11681-11684. (CC Mastick was CC Cain)

Mastick, CC, R. Aebersold, and G.E. Lienhard (1994) Characterization of a Major Protein in GluT4 Vesicles: Concentration in the Vesicles and Insulin-Stimulated Translocation to the Plasma Membrane. J. Biol. Chem., 269, 6089-6092.

Wiese, RJ, CC Mastick, DF Lazar, and AR Saltiel (1995) Activation of MAP kinase and Phosphatidylinositol 3'-Kinase is not Sufficient for the Hormonal Stimulation of Glucose Uptake, Lipogenesis, or Glycogen Synthesis in 3T3-L1 Adipocytes. J. Biol. Chem., 270, 3442-3446.

Mastick CC, Aebersold R, Lienhard GE.. Characterization of a major protein in GLUT4 vesicles. Concentration in the vesicles and insulin-stimulated translocation to the plasma membrane. (1994) J. Biol. Chem., 269, 6089-6092.

Mastick CC, Brady MJ, Saltiel AR. (1995) Insulin stimulates the tyrosine phosphorylation of caveolin. J. Cell Biol., 129, 1523-1531.

Cao, H, WE Courchesne, and CC Mastick (2002) A Phosphotyrosine-Dependent Dihybrid Yeast Protein Interaction Screen Reveals a Role for Phosphorylation of Caveolin-1 on Tyrosine 14: Recruitment of CSK to Caveolae. Accelerated Publication, J. Biol. Chem., 277:8771-8774.

Sanguinetti, A.R. and C.C. Mastick (2003) cAbl Expression is Required for Oxidative Stress-Induced Phosphorylation of Caveolin-1 on Tyrosine 14. Cellular Signalling, 15:289-298.

Sanguinetti, A.R., H. Cao, and C.C. Mastick (2003) Fyn is Required for Oxidative and Hyper-osmotic Stress-Induced Phosphorylation of Caveolin-1. Biochem J., 376: 159-168.

Cao, H., A.R. Sanguinetti, and C.C. Mastick (2004) Oxidative Stress Activates both Src-Kinases and their Negative Regulator Csk and Induces Phosphorylation of Two Targeting Proteins for Csk: Caveolin-1 and Paxillin. Exp. Cell Res. 294:159-171.

Muretta, J., I. Romenskaia, Cassiday, P.A., and C.C. Mastick A (2006) Expression of a Synapsin IIb Site 1 Phosphorylation Mutant in Adipocytes Blocks Basal Intracellular Retention of GluT4. Submitted.

Muretta, J., I. Romenskaia, Cassiday, P.A., and C.C. Mastick A (2006) Expression of a Synapsin IIb Site 1 Phosphorylation Mutant in Adipocytes Redistributes GluT4 from Statically Retained Storage Compartments into Recycling Endosomes. Submitted.

Muretta, J. and C.C. Mastick A (2006) A Novel Flow Cytometeric Assay to Study GluT4 Traffic in Adipocytes: Cell Confluency and Degree of Differentiation Strongly Affect Basal Static Retention of GluT4. In preparation.