HOME | About NAES | Research | Scientists | Departments | Facilities | Resources | Publications | Relevant Links

Ron Pardini

 

Photo of Ron Pardini


Associate Director NAES
Department of CABNR/NAES - Administration
University of Nevada/Mail Stop 221
1664 North Virginia Street
Reno,  Nevada   89557

 

Office: (775) 784-6237
Lab: 784-4107

Fax: 784-6604

Email: ronp@cabnr.unr.edu
Building: Max Fleischmann Agriculture,  Office 210 
 
View Photo Gallery: 
Click Here

 

Download Electronic Business Card OR vCard

 

EDUCATION

B.Sc. Chemistry 1961 California State Poly College
Ph.D. Food Science, Biochemistry, 1965 University of Illinois

 

ACADEMIC & RESEARCH INTEREST

One of the most exciting projects in our laboratory is the investigation of the role of nutritional intervention in cancer therapy. We are demonstrating that different types and levels of dietary fat can slow tumor growth rates, increase tumor responsiveness to therapy, lower drug-host toxicity of certain anticancer agents, and reduce cachexia- the wasting syndrome associated with cancer victims. This research is working toward a nutritional-intervention clinical trial designed to improve the outcome of chemotherapy and patient well-being.

Our laboratory is also investigating the induction of oxidative stress by various chemicals in insects and cancer. More specifically we are investigating the biochemistry and molecular biology of antioxidant systems of insects and tumor cells in order to predict mechanisms of insect resistance to plant allelochemicals and other foreign chemicals. In addition, we are investigating the mechanisms of tumor cell resistance to pro-oxidant anti-cancer agents.

These projects have potential for the selective destruction of insect pests and the selective survival of specific plant species. We are utilizing our insect model system to predict oxidative stress from various xcuobiotics including environmental pollutants. In addition, this approach would predict a tumor cell's sensitivity or resistance to pro-oxidant anti-tumor agents.

BLOG SITES

 
COMMUNITY SERVICE

New Drug Treatments

One of our primary interests in cancer research is to find new potential anticancer agents from natural products. We have a particular interest in a novel chemical called hypericin which comes from plants in the Hypericum genus. Hypericum perforatum, commonly known as St. Johnswort, is a hardy drought-resistant plant that grows in Nevada and Northern California. It is rich in medicinal folklore history and is an abundant source of hypericin.

Hypericin is light-activated and therefore a potential drug for photodynamic therapy of cancer. We have demonstrated hypericin's light-activated anticancer activity by treating experimental tumors with the drug. The chemotherapeutic activity is realized when light is shined directly upon the tumor cells. In this way, we hope to find preferential activation and toxicity in the tumor and to minimize toxic side effects in the rest of the body. This new exciting type of therapy offers hope in the fight against cancer.

Support

The Cancer Research Laboratory receives support from the State of Nevada through the Allie M. Lee Cancer Research Fund. Significant support is also received from private donors, memorial funds and the successful fund-raising efforts of civic groups like the Grand Chapter of Nevada, Order of the Eastern Star and the Ladies Auxiliary to the Veterans of Foreign Wars of the United States. All private monies donated to the Cancer Research Laboratory are unique in that they go directly to research. No administrative or overhead costs are deducted. This assures that private donations are used in their entirety in the fight against cancer.

The Facility

The Cancer Research Laboratory and Reno Cancer Center Athymic "nude" Mouse Facility is located in the Howard Medical Sciences Building at the University of Nevada, Reno. This modern facility is housed in the Department of Biochemistry at the School of Medicine Complex provides an educational environment where research professors, lab technicians, post-doctoral fellows and students work together utilizing established pre-clinical models to solve problems in cancer research.

Gifts

All donations to the Cancer Research Laboratory are used in their entirety for research to further the treatment of cancer. No administrative or overhead costs are deducted. Contributions to the Cancer Research Laboratory are tax deductible to the extent authorized by law and can be sent to:

University of Nevada, Reno
Foundation/162
Cancer Research Gifts
Reno, NV 89557
Make checks payable to:
Board of Regents: Cancer Gifts Acct # 1301-152-0020

Acknowledgments of memorial gifts to the surviving parties will be made at the request of the donor.

 If you have questions regarding our work at the Cancer Research Laboratory, please contact us at:

University of Nevada, Reno
Cancer Research Laboratory
Department of Biochemistry and Molecular Biology/ 330
Reno, Nevada 89557

 
REPRESENTATIVE PUBLICATIONS

 

Journals
Kristina R.Rogers, Keith D.Kikawa, Michael Mouradian, Karla Hernandez, Kristen M.McKinnon, Shayne M.Ahwah and Ronald S.Pardini 2010, Docosahexaenoic acid alters epidermal growth factor receptor-related signaling by disrupting its lipid raft association, Carcinogenesis vol.31 no.9 pp.1523–1530   Read More...
Kikawa KD, Herrick JS, Tateo RE, Mouradian M, Tay JS, Pardini RS 2009, Induced oxidative stress and cell death in the A549 lung adenocarcinoma cell line by ionizing radiation is enhanced by supplementation with docosahexaenoic acid, Nutrition and Cancer: An International Journal   Read More...
T. Kato, N. Kolenic, and R. S. Pardini 2007, Docosahexaenoic Acid (DHA), a Primary Tumor Suppressive Omega-3 Fatty Acid, Inhibits Growth of Colorectal Cancer Independent of p53 Mutational Status, Nutrition and Cancer, 58(2), 178–187  
Ronald S. Pardini 2006, Nutritional intervention with omega-3 fatty acids enhances tumor response to anti-neoplastic agents, Chemico-Biological Interactions 162 (2006) 89–105   Read More...
R. S. Pardini, D. Wilson, S. Schiff, S. A. Bajo, and R. Pierce 2005, Nutritional Intervention With Omega-3 Fatty Acids in a Case of Malignant Fibrous Histiocytoma of the Lungs, Nutrition and Cancer, 52(2), 121–129  
Kato, T., R. Hancock. M. Mohammadpour, B. McGregor, P. Manalo, S. Khaiboullina, M.R. Hall, L. Pardini and R.S. Pardini 2002, Influence of Omega-3 fatty acids on the growth of human colon carcinoma in nude mice, Cancer Letters 187, 169-177.  
H. Mohammadpour, M.R. Hall, R.S. Pardini, L. L. Pardini, S.F. Khaiboullina, P. Manalo, B. McGregor 2000, Tumor Development and Cytopkine Production by HumanColon Tissues and Carcinoma Cell Lines, J. Surg. Invest., 2, 65-72.