PUBLICATIONS:
Theses:
1990 (M.Sc.) Characterization of Hydrogen Peroxide Removal Mechanisms in The Cyanobacterium Synechococcus PCC 7942 (R-2).
Advisor: Professor Elisha Tel-Or.
1993 (Ph.D.) Molecular Characterization of Pea Cytosolic Ascorbate Peroxidase.
Advisor: Professor Barbara A. Zilinskas.
1. Mittler, R. and Tel-Or, E. (1991) Oxidative stress response and shock proteins in the unicellular cyanobaterium Synechococcus R2 (PCC 7942). Arch. Microbiol. 155, 125-131.
2. Mittler, R. and Tel-Or, E. (1991) Oxidative stress response in the unicellular cyanobacterium Synechococcus R2 (PCC 7942). Free Radical Res. Comm. 12, 845-850.
3. Mittler, R., Nir, M. and Tel-Or, E. (1991) Antiperoxidative enzymes in Retama and their seasonal variation. Free Radical Res. Comm. 14, 17-25.
4. Rozen, A., Mittler, R. and Tel-Or, E. (1991) A unique ascorbate peroxidase activity in the cyanobacterium Synechococcus PCC 7942 (R2). Free Radical Res. Comm. 17, 1-8.
5. Mittler, R. and Zilinskas, B. (1991) Purification and characterization of pea cytosolic ascorbate peroxidase. Plant Physiol. 97, 962-968.
6. Mittler, R. and Zilinskas, B. (1991) Molecular cloning and nucleotide sequence analysis of a cDNA encoding pea cytosolic ascorbate peroxidase. FEBS Lett. 289, 257-259.
7. Mittler, R. and Zilinskas, B. (1992) Molecular cloning and characterization of a gene encoding pea cytosolic ascorbate peroxidase. J. Biol. Chem. 267, 21802-21807.
8. Mittler, R. and Zilinskas, B. (1993) Detection of ascorbate peroxidase activity in native gels by inhibition of the ascorbate-dependent reduction of nitroblue tetrazolium. Anal. Biochem. 212, 540-546.
9. Mittler, R. and Zilinskas, B. (1994) Regulation of pea cytosolic ascorbate peroxidase and other antioxidant enzymes during the progression of drought stress and following recovery from drought. Plant J. 5, 397-406.
10. Mittler, R., Shulaev, V. and Lam E. (1995) Coordinated activation of programmed cell death and defense mechanisms in transgenic tobacco plants expressing a bacterial proton pump. Plant Cell 7, 29-42.
11. Mittler, R. and Lam, E. (1995) In situ detection of nDNA fragmentation during the differentiation of tracheary elements in higher plants. Plant Physiol. 108, 489-493.
12. Mittler, R. and Lam, E. (1995) Identification, characterization, and purification of a tobacco endonuclease activity induced upon hypersensitive response cell death. Plant Cell 7, 1951-1962.
13. Mittler, R., Shulaev, V., Seskar, M. and Lam, E. (1996) Inhibition of programmed cell death in tobacco plants during pathogen-induced hypersensitive response at low oxygen pressure. Plant Cell 8, 1991-2001.
14. Mittler, R., Simon, L. and Lam, E. (1997) Pathogen-induced programmed cell death in tobacco. J. Cell Science 110, 1333-1344.
15. Mittler, R. and Lam, E. (1997) Characterization of nuclease activities and DNA fragmentation induced upon hypersensitive response cell death and mechanical stress. Plant Mol. Biol. 34, 209-221.
16. Mittler, R., Del Pozo, O., Meisel, L. and Lam, E. (1997) Pathogen-induced programmed cell death in plants: a possible defense mechanism. Developmental Genetics 21, 279-289.
17. Mittler, R., Feng, X. and Cohen, M. (1998) Post-transcriptional suppression of cytosolic ascorbate peroxidase expression during pathogen-induced programmed cell death in tobacco. Plant Cell 10, 461-474.
18. Mittler, R., Shulaev, V., Lam, E. and Cohen, M. (1999) Signals controlling the expression of cytosolic ascorbate peroxidase during pathogen-induced programmed cell death in tobacco. Plant Mol. Biol. 39, 1025-1035.
19. Mittler, R., Hallak-Herr, E., Orvar, B.L., Van Camp, W., Willekens, H., Inze, D. and Ellis, B.E. (1999) Transgenic tobacco plants with reduced capability to detoxify reactive oxygen intermediates are hyper-responsive to pathogen infection. Proc. Natl. Acad. Sci. USA. 96, 14165-14170.
20. Mittler, R., Merquiol, E., Hallak-Herr, E., Kaplan, A., and Cohen, M. (2001) Living under a "dormant" canopy: a molecular acclimation mechanism of the desert plant Retama raetam. Plant J. 25, 407-416. (cover photo)
21. Rizhsky, L. and Mittler, R. (2001) Inducible expression of bacterio-opsin in transgenic tobacco and tomato plants. Plant Mol. Biol. 46, 313-323.
22. Pekker, I., Tel-Or, E. and Mittler, R. (2002) Reactive oxygen intermediates and glutathione regulate the expression of cytosolic ascorbate peroxidase during iron-mediated oxidative stress in bean. Plant Mol. Biol. 49, 429-438.
23. Dominique P., Mittler R. and Lam E. (2002) Mechanism of cell death and disease resistance induction by transgenic expression of bacterio-opsin Plant J. 30, 499-509.
24. Pnueli, L., Hallak-Herr, E., Rozenberg, M., Cohen, M., Goloubinoff, P., Kaplan, A. and Mittler, R. (2002) Molecular and biochemical mechanisms associated with dormancy and drought tolerance in the desert legume Retama raetam. Plant J. 31, 319-330.
25. Rizhsky, L. Hallak-Herr, E., Van Breusegem, F., Rachmilevitch, S., Rodermel, S., Inzé, D. and Mittler, R. (2002) Double antisense plants with suppressed expression of ascorbate peroxidase and catalase are less sensitive to oxidative stress than single antisense plants with suppressed expression of ascorbate peroxidase or catalase. Plant J. 32, 329-342.
26. Merquiol, E., Hallak-Herr, E., Kaplan, A., Cohen, M. and Mittler, R. (2002) Seasonal and diurnal variations in gene expression in the desert legume Retama raetam Plant Cell & Environment. 25, 1627-1638.
27. Rizhsky, L., Hongjian, L. and Mittler, R. (2002) The combined effect of drought stress and heat shock on gene expression in tobacco. Plant Physiol. 130, 1143-1151.
28. Kaplan, A., Lieman-Hurwitz, J., Mittler, R., Ronen-Tarazi, M., Bonfil, D. and Schatz, D (2003) Enhancing Inorganic Carbon Fixation by Photosynthetic Organisms. Plant Biotech. 1, 43-50.
29. Pnueli, L., Hongjian, L. and Mittler, R. (2003). Growth suppression, abnormal guard cell response, and augmented induction of heat shock proteins in cytosolic ascorbate peroxidase (Apx1) - deficient Arabidopsis plants. Plant J. 34, 187-203.
30. Rizhsky L, Liang H, Mittler R. (2003) The water-water cycle is essential for chloroplast protection in the absence of stress. J. Biol. Chem. 278, 38921-38925.
31. Rizhsky L., Liang H., Shuman J., Shulaev V., Davletova S. and Mittler R. (2004) When defense pathways collide: The response of Arabidopsis to a combination of drought and heat stress. Plant Physiol. 134, 1683-1696.
32. Rizhsky L., Davletova
S., Liang H. and Mittler R. (2004) The zinc-finger protein Zat12 is required for
cytosolic ascorbate peroxidase 1 expression during oxidative stress in
Arabidopsis. J. Biol. Chem. 279, 11736-11743.
33.
Davletova S, Rizhsky L, Liang H,
Shengqiang Z, Oliver DJ, Coutu J, Shulaev V, Schlauch K, Mittler R (2005)
Cytosolic ascorbate peroxidase 1 is a central component of the
reactive oxygen gene network of Arabidopsis. Plant Cell 17,
268-281.
34. Davletova S, Schlauch K, Coutu J,
Mittler R (2005) The zinc-finger protein Zat12 plays a central role
in reactive oxygen and abiotic stress signaling in Arabidopsis.
Plant
Physiol.
139, 847-856.
35.
Suzuki N, Rizhsky L, Liang H, Shuman J,
Shulaev V, Mittler R (2005) Enhanced tolerance
to environmental stress in transgenic plants
expressing the transcriptional co-activator
MBF1. Plant
Physiol.
in press.
36.
Gollery M, Harper J, Cushman
J, Mittler T, Girke T, Zhu J-K, Bailey-Serres J, Mittler R (2005) What makes
species unique? A role for genes with unknown function.
PNAS
submitted.
Review Papers:
37. Mittler, R. and Lam, E. (1996) Sacrifice in the face of foes: pathogen-induced programmed cell death in higher plants. Trends Microbiol. 4, 10-15.
38. Mittler, R. and Rizhsky, L. (2000) Transgene-induced lesion mimics. Plant Mol. Biol. 44, 335-344. (cover photo).
39. Mittler, R. (2002) Oxidative stress, antioxidants, and stress tolerance. Ternds Plant Sci. 7, 405-410.
40. Mittler. R., Vanderauwera, S., Gollery, M., Van Breusegem, F. (2004) The reactive oxygen gene network of plants. Trends Plant Sci. 9, 490-498.
41. Suzuki N, Mittler R (2005) Reactive oxygen and temperature stress. Physiol. Plant. in press.
42. Miller G. and Mittler R (2005) Reactive oxygen metabolism. Ann. Bot. invited.
43. Mittler. R (2005) Abiotic Stress, the Field Environment and Stress Combination. Trends Plant Sci. invited.
Commentary:
44. Mittler, R. and Berkowitz, G. (2001) Hydrogen peroxide, a messenger with too many roles? Pei Z.M., Murata Y., Benning G. et al, Nature 2000; 406: 731-734. Redox Report 6, 69-72.
Patents:
U.S. Patent No. 5,629,470 entitled "Transgenic Plants and Plant Cells with Enhanced Pathogen Resistance and Related Methods"; International Application Number: PCT/US96/00741 (Jan. 1996); Inventors: Lam, E. and Mittler, R.
U.S. Patent No. entitled "Enhancing Inorganic Carbon Fixation by Photosynthetic Organisms". Inventors: Kaplan, A., Lieman-Hurwitz, J., Mittler, R., Ronen-Tarazi, M., Bonfil, D. and Schatz, D. (Pending).
Book Chapters:
1. Mittler, R. (1998) Cell death in plants. In: When Cells Die, A Comprehensive Evaluation of Apoptosis and Programmed Cell Death, Z. Zakeri, J.Tilly, R.A. Lockshin (eds.), John Wiley & Sons, pp. 147-174.
2. Cheung, A. and Mittler R. (2003) Programmed cell death in plants. In: When Cells Die II, A Comprehensive Evaluation of Apoptosis and Programmed Cell Death, Z. Zakeri, J.Tilly, R.A. Lockshin (eds.), John Wiley & Sons. pp. 99-122.
3. Mittler, R. and Zilinskas, B. (2003) Active oxygen species in multiple stress situations and protective systems. In: Ecological Studies Vol. 170. Springer, Berlin. pp 51-70.
4. Mittler, R. and Shulaev, V. (2003) Programmed cell death in plants: future perspectives, applications and methods. In: Programmed Cell Death in Plants, J. Gray (ed.) Blackwell Publishing. Oxford, UK pp. 251-264.
5. Rizhsky, L. Shulaev, V. and Mittler, R. (2004) Measuring apoptosis in plant cells. In: Apoptosis Methods and Protocols, Methods in Molecular Biology. Humana Press. pp. 179-190.
6. Shulaev, V. and Mittler, R. (2004) Programmed cell death in plant yeast and bacteria. In: Essentials of Apoptosis. Humana Press. pp. 125-134.
7. Mittler R. (2004) The Hypersensitive Response. In: Encyclopedia of Plant and Crop Science(online) Marcel Dekker, Inc. New York. NY
8. Mittler R. (2005) Ascorbate Peroxidase. In: Antioxidants and reactive oxygen species in plants. Edited by N. Smirnoff. Blackwell Publishing. Oxford, UK. In press.
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