Robert Ryan


Professor - Department Chair

Department of Biochemistry and Molecular Biology
University of Nevada/Mail Stop 330
1664 N. Virginia Street
Reno,  Nevada   89557

Office: (775) 682-7332
Email: robertryan@unr.edu
Building: Howard Medical Science,  Office 145C

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EDUCATION
B.S. University of Nevada, 1977
Ph.D. University of Nevada, 1982

ACADEMIC & RESEARCH INTEREST

Heart disease is a major cause of mortality in North America. While it is clear that development of cardiovascular disease is a multi-factorial process, it is evident that aberrations in lipid metabolism represent a significant risk factor. It is widely accepted that exchangeable apolipoproteins function in regulation of plasma lipid levels, yet the molecular basis for this role is not fully understood. Increased knowledge of the properties of exchangeable apolipoproteins will be useful in the development of therapeutic strategies to influence plasma lipid levels and thereby, reduce the risk of cardiovascular disease. Furthermore, by understanding the molecular basis of apolipoprotein function in lipid transport and metabolism, it should be possible to design strategies to enhance or interfere with biological processes dependent upon their action. Knowledge gained has direct relevance to the treatment of dyslipidemias, including hypercholesterolemia and disorders of lipid metabolism that affect children and adults.

REPRESENTATIVE PUBLICATIONS

Journals
Ikon N, Ryan RO. 2017, Barth Syndrome: Connecting Cardiolipin to Cardiomyopathy., Lipids. 2017 Feb;52(2):99-108.
Ikon N, Ryan RO. 2017, Cardiolipin and mitochondrial cristae organization., Biochim Biophys Acta. 2017 Jun;1859(6):1156-1163.
Forte TM, Sharma V, Ryan RO 2016, Apolipoprotein A-V gene therapy for disease prevention / treatment: a critical analysis., J Biomed Res. 2016 Mar;30(2):88-93.
Zhang LS, Sato H, Yang Q, Ryan RO, Wang DQ, Howles PN, Tso P. 2015, Apolipoprotein A-V is present in bile and its secretion increases with lipid absorption in Sprague-Dawley rats., Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G918-25
Forte TM, Ryan RO. 2015, Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride Metabolism., Curr Drug Targets. 2015;16(12):1274-80. Review.
Ryan RO 2015, Metabolic annotation of 2-ethylhydracrylic acid., Clin Chim Acta. 2015 Aug 25;448:91-7
Ghosh M, Ryan RO. 2014, Curcumin homing to the nucleolus: mechanism for initiation of an apoptotic program., J Nutr Biochem. 2014 Nov;25(11):1117-1123.