Maria Valencik


Photo of Maria Valencik

Associate Professor

Department of School of Medicine - UNR
University of Nevada/Mail Stop 330
1664 North Virginia Street
Reno,  Nevada   89557

Office: (775) 784-1389
Lab: 784-6630

Fax: 784-1419

Email: mvalen@unr.edu
Building: Howard Medical Science,  Office 166

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EDUCATION
B.A. University of California-Berkeley(1984)
Ph.D. University of California Los Angeles (1991)

ACADEMIC & RESEARCH INTEREST

We study the role of integrins, dimeric receptors for extracellular matrix, in cardiac myocytes. Integrins are interposed between the contractile machinery of the cardiac muscle and the extracellular matrix skeleton of the heart. The integrin receptors serve as mechanosensors, translating mechanical stress into chemical signals. We study this process using a novel transgenic mouse system, in which integrin expression by cardiac myocytes is turned on and off using a chemical switch (Transgenic Research 10: 269-75). Using a similar approach, we are studying the role of the natriuretic peptide system in mediating diastolic left ventricular function. These projects are ideal for students wishing to learn more about the basic pathobiology of the heart using molecular, cell, transgenic and physiological approaches.

AWARDS, HONORS, & PROFESSIONAL RECOGNITION

Departmental Honors and University Distinction from University of California, Berkeley 1984

REPRESENTATIVE PUBLICATIONS